Francesco Spinacino (fl. 1507) was an Italian lutenist and composer. His surviving output comprises the first two volumes of Ottaviano Petrucci's influential series of lute music publications: Intabolatura de lauto libro primo and Intabolatura de lauto libro secondo (both 1507). These two collections comprise the first known printed lute music. Spinacino was apparently highly regarded by his contemporaries, as his music was widely copied: some of the pieces are found in manuscripts that originated in the British Isles.