Trisomie 21 (Literally, a 21st chromosome trisomy, also knows as Down Syndrome), is a group by Philippe Lomprez and Hervé Lomprez, two brothers from Lille, France. Hervé is a Professor of Sounds Technology. Their early music is considered French coldwave (an early cousin of "darkwave"), while their later music electro-pop. Throughout the 80's and 90's, T21 was signed to PIAS Records and their most popular song was "The Last Song". In 2003, Trisomie 21 remixed "Le Grand Secret" by Indochine which featured Melissa Auf Der Maur from Hole.